APILIMOD
- Product Name
- APILIMOD
- CAS No.
- 541550-19-0
- Chemical Name
- APILIMOD
- Synonyms
- Sta5326;Sta-5326;Sta 5326;APILIMOD;APILIMODUM;Apilimod, >98%;ApiliMod(STA5326);Apilimod Hydrochloride;STA 5326; STA5326; STA-5326;Benzaldehyde,3-methyl-,2-[6-(4-morpholinyl)-2-[2-(2-pyridiny...
- CBNumber
- CB61091430
- Molecular Formula
- C23H26N6O2
- Formula Weight
- 418.49
- MOL File
- 541550-19-0.mol
APILIMOD Property
- Boiling point:
- 655.1±65.0 °C(Predicted)
- Density
- 1.24
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- pka
- 12.56±0.10(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-2341
- Product name
- Apilimod
- Purity
- 99.61%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-2341
- Product name
- Apilimod
- Purity
- 99.61%
- Packaging
- 10mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-2341
- Product name
- Apilimod
- Purity
- 99.61%
- Packaging
- 50mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- SYN5487
- Product name
- Apilimod
- Packaging
- 10mg
- Price
- $156.92
- Updated
- 2021/12/16
- Product number
- API0004744
- Product name
- 4'-ACETYL-BIPHENYL-4-CARBOXYLIC ACID (4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYL)-AMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $288.2
- Updated
- 2021/12/16
APILIMOD Chemical Properties,Usage,Production
Description
Apilimod (541550-19-0) is a potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 inhibitor downregulating both at the transcriptional level.? Suppresses Th1 but not Th2 immune response.1? Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells.? Apilimod’s mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve; IC50 = 14 nM).2? It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3? Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4
Chemical Properties
Off-White Solid
Uses
Apilimod is a small-molecule that selectively suppresses synthesis of IL-12 and IL-23. Apilimod reduces dendritic cell infiltration in psoriasis.
References
Wada et al. (2007), Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL23 inhibitor; Blood 109 1156 Cai et al. (2013), PIKfyve, a class III PI-kinase, is the target of the small molecule IL12/23 inhibitor apilimod and a new player in toll-like receptor signaling; Chem. Biol., 20 912 Gayle et al. (2016), Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma; Blood, 129 1768 Kang et al. (2020), Inhibition of PIKfyve kinase prevents infection by Zaire ebola virus and SARS-CoV-2; Proc. Natl. Acad. Sci. USA 117 20803
APILIMOD Preparation Products And Raw materials
Raw materials
Preparation Products
APILIMOD Suppliers
- Tel
- 00852-68527855
- Fax
- 00852-26406298
- info@itopbiochem.com
- Country
- China Hong Kong
- ProdList
- 902
- Advantage
- 58
View Lastest Price from APILIMOD manufacturers
- Product
- APILIMOD 541550-19-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week 100kg
- Release date
- 2019-09-05